Fen-Phen
This guide is an introductory list to help locate research materials at the Rowland Medical Library. Fen-Phen, a combination of the appetite suppressants fenfluramine and phentermine, is a once popular pharmacological treatment for obesity. In 1997, the Food and Drug Administration asked the manufacturers of fenfluramine to voluntarily withdraw their product from the market. This action was taken by the FDA because of new evidence linking the use of fenfluramine to heart valve problems (New England Journal of Medicine. 337(9): 581-88, 1997).
Handbooks, encyclopedias, dictionaries / Selected textbooks / More books / Selected journals / More journals / Selected indexes and abstracts / Selected journal articles / Specialized sources / Selected electronic sources
Handbooks, encyclopedias, dictionaries
American Society of Health-System Pharmacists. AHFS Drug Information 2007,
REF QV 740 .AA1 A512 2007Bray, George A., et al (eds.). Handbook of obesity.
WD 210 H266c 2004Cassell, Dana K. and Felix Larocca. Encyclopedia of obesity and eating disorders. p.100-101, 161, 235
WD 210 C277 2000Stunkard, Albert J. and Thomas A. Wadden (eds.). Obesity: theory and therapy, 2d ed. p.278-280
WD 210 O237 1993
Alpert, Martin A. and James K. Alexander (eds.). The heart and lung in obesity. p. 207-208
WD 210 H427 1998Blackburn, George L. and Beatrice S. Kanders (eds.). Obesity: pathophysiology, psychology and treatment. p. 285-289
WD 210 O235 1994Fairburn, Christopher G. and G. Terrence Wilson (eds.). Binge eating: nature, assessment, and treatment. p. 251, 259, 261
WM 175 B563 1993Fletcher, G., et al (eds.). Obesity: impact on cardiovascular disease. p. 297, 305-306
WD 210 O145 1999Silverstone, T. Drugs and appetite. p. 26-27, 93-95, 126-129, 141-143
WI 210 D78 1982VanItallie, Theodore B. and Artemis P. Simopoulos (eds.). Obesity: new directions in assessment and management. p. 228-229
WD 210 O263 1995
Search RoMeO Public Access Catalog
Suggested subject headings: Obesity Obesity - Therapy Body Weight
Addictive behaviors
American journal of clinical nutrition
Circulation
International journal of eating disorders
International journal of obesity and related metabolic disorders
Search RoMeO Public Access Catalog
Suggested subject headings: Obesity - Periodicals Pharmacology - Periodicals
Selected indexes and abstracts
Index Medicus & MEDLINE Database
Suggested subject headings: Fenfluramine Phentermine Appetite Depressants Obesity/dt (MEDLINE only) Anti-Obesity Agents Serotonin Uptake Inhibitors
Search using keywords: Fen-Phen Fenfluramine Phentermine Pondimin Redux International Pharmaceutical Abstracts
Search using keywords: Fenfluramine Phentermine
Blanck HM, et al. Prescription weight loss pill use among Americans: patterns of pill use and lessons learned from the fen-phen market withdrawal. Prev Med. 2004 Dec;39(6):1243-8.
Zolkowska D, et al. Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. J Pharmacol Exp Ther. 2006 Aug;318(2):604-10. Epub 2006 Apr 27.
Wee S, et al. Self-administration of mixtures of fenfluramine and amphetamine by rhesus monkeys. Pharmacol Biochem Behav. 2006 Jun;84(2):337-43. Epub 2006 Jul 10.
Walker AM, et al. Temporal trends and drug exposures in pulmonary hypertension: an American experience. Am Heart J. 2006 Sep;152(3):521-6.
Whigham LD, et al. Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status. Int J Obes (Lond). 2007 May;31(5):850-7. Epub 2006 Dec 5.
Greffe G, et al. Valvular heart disease associated with fenfluramine detected 7 years after discontinuation of treatment. Ann Thorac Surg. 2007 Apr;83(4):1541-3.
Fleming RM, et al. The longitudinal effects of fenfluramine-phentermine use. Angiology. 2007 Jun-Jul;58(3):353-9.
Fernstrom JD, et al. The development of tolerance to drugs that suppress food intake. Pharmacol Ther. 2007 Sep 20; [Epub ahead of print]
Souza R, et al. Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases. Eur Respir J. 2007 Oct 24; [Epub ahead of print]
Zolkowska D, et al. Chronic Fenfluramine Administration Increases Plasma Serotonin (5-HT) to Non-Toxic Levels. J Pharmacol Exp Ther. 2007 Nov 21; [Epub ahead of print]
Department of Psychiatry 601-984-6925
University of Mississippi Medical Center, Jackson
William Woolverton, PhD wwoolverton@psychiatry.umsmed.eduDepartment of Pediatrics 601-984-5250
University of Mississippi Medical Center, Jackson
J. Clinton Smith, MD csmith@ped.umsmed.edu
CNN interactive: Health
http://www.cnn.com/HEALTH/9707/08/fenphen.reportMayo Clinic & Foundation for Medical Education and Research
http://www.mayo.edu/RxList - the Internet Drug Index
http://www.rxlist.com/
Author: Michelle Malizia
Copyright 1997, Rev. 1999, 2002, 2007 Gongchao Yang, Reference Department,
Rowland Medical Library,
University of Mississippi Medical Center, Jackson